| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5828146 | European Journal of Pharmacology | 2013 | 4 Pages |
Abstract
Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.
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Authors
Filippo Renò, Manuela Rizzi, Marco Invernizzi, Mario Migliario, Carlo Cisari,