Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5829523 | European Journal of Pharmacology | 2012 | 7 Pages |
Abstract
Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB4- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB4- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB4, decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue.
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Authors
Raphael G. Ferreira, Tamires C. Matsui, Adriana M. Godin, Lindisley F. Gomides, Pedro E.M. Pereira-Silva, Igor D.G. Duarte, Gustavo B. Menezes, Márcio M. Coelho, André Klein,