Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5829639 | European Journal of Pharmacology | 2012 | 5 Pages |
Abstract
Cardiovascular baroreceptor responsiveness of conscious rats treated with selective inhibitors of monoamine oxidase (MAO) types A and B was determined by measurement of blood pressure (BP) and heart rate (HR) responses to intravenous injection of phenylephrine and sodium nitroprusside. Treatment with selegiline (1 or 5Â mg/kg p.o. daily for 7Â days) did not significantly modify resting levels of BP and HR, lower or upper HR plateau levels, or HR/BP gain. Treatment with clorgyline (2Â mg/kg p.o. daily for 7Â days) increased HR/BP gain but also did not modify resting BP or HR, or lower and upper plateau levels of HR. The results are compatible with an effect of MAO-A inhibition to modify monoamine levels in medullary areas participating in CNS control of blood pressure.
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Authors
Orit Bar-Am, Aviva Gross, Rachel Friedman, John P.M. Finberg,