| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5830104 | European Journal of Pharmacology | 2011 | 8 Pages |
Abstract
⺠Sepsis and endotoxemia induces organ damage and cardiovascular dysfunction. ⺠Early pharmacological inhibition of NOS-1 greatly improves these conditions. ⺠NOS-1 gene knockout reduced mortality by endotoxemia. ⺠A short initial pulse of NO is critical for the onset of these changes. ⺠NOS-1-derived NO is a key signaling factor in the initiation of systemic inflammation.
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Authors
Danielle Duma, Daniel Fernandes, Marcelo G. Bonini, Krisztian Stadler, Ronald P. Mason, Jamil Assreuy,