| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5830429 | European Journal of Pharmacology | 2011 | 9 Pages |
Abstract
The transcription factor c-jun is significantly reduced while c-fos becomes up regulated after cAMP elevation. However an electrophoretic mobility shift assay with the activator protein-1 motif present in the promoter of the rat NPP1 gene indicates that this motif is not involved in the cAMP-dependent inhibition of NPP1 expression. In conclusion, these results indicate that intracellular cAMP levels regulate the expression of NPP1 in rat C6 glioma cells by a signalling pathway that is different from the GFAP signal transduction pathway.
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Authors
Indra Aerts, Bert Grobben, Xaveer Van Ostade, Herman Slegers,