| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5831827 | International Immunopharmacology | 2016 | 9 Pages |
Abstract
These results showed that PGL markedly enhanced the anti-inflammatory activity of IND and this effect mediated partly at least, through PPARγ. Possible mechanisms of the interaction were that PGL stimulates the PPARγ and inhibits COX-2 by those cytokines that trigger the PPARγ and also inhibit COX-2. This study suggests that combination therapy with pioglitazone and indomethacin may provide an alternative for the clinical control of inflammation especially in patients with diabetes.
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Authors
Gholamreza Houshmand, Mohammad Taghi Mansouri, Bahareh Naghizadeh, Ali Asghar Hemmati, Mahmoud Hashemitabar,