| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5831882 | International Immunopharmacology | 2016 | 7 Pages |
Abstract
The 1-methylnicotinamide (MNA) inhibited concanavalin A (Con A)-induced inflammatory liver injury by PGI2 dependent inhibition of IL-4 release from lymphocytes and subsequent decrease in TNF-α. The direct effect of MNA-released PGI2 on TNF-α production by Kupffer cells may also be involved in the hapatoprotective effect of MNA (Ohta et al., 2005; Nakamura et al., 1998).
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Authors
Andrzej Jakubowski, Magdalena Sternak, Konrad Jablonski, Marta Ciszek-Lenda, Janusz Marcinkiewicz, Stefan Chlopicki,