| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5832106 | International Immunopharmacology | 2015 | 7 Pages |
Abstract
Thus, current results on bone properties of 16-week old female M3R-KO are related to postmenopausal osteoporotic phenotype. Stimulation and up-regulation of muscarinic acetylcholine receptor subtype M3 expression in osteoblasts might be a possible new option for prevention and therapy of osteoporotic fractures. Pharmacological interventions and the risk of side effects have to be determined in upcoming studies.
Keywords
DXATbPfTbThTbNCaHACTSKM3RSMITMDTRAPnAChRmAChRBMDRANKLROIBMCBCIP/NBTBV/TVALPAlkaline phosphataseOsteocyteTemBiomechanicsBone mineral densityTissue mineral densitydual-energy X-ray absorptiometryMinBending stiffnessminutesRankReal-time RT-PCRStructure model indextrabecular numbertrabecular thicknessBone mineral contentregion of interestThoracic VertebraeLumbar VertebraeTransmission electron microscopywild typehematoxylin-eosincalcium hydroxyapatitemuscarinic acetylcholine receptornicotinic acetylcholine receptorscholinergic receptorReceptor activator of nuclear factor κBReceptor activator of nuclear factor κB ligand
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Authors
Katrin Susanne Lips, Mathias Kneffel, Fee Willscheid, Frank Martin Mathies, Marian Kampschulte, Sonja Hartmann, Imke Panzer, Lutz Dürselen, Christian Heiss, Vivien Kauschke,