Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5832394 | International Immunopharmacology | 2015 | 9 Pages |
Abstract
This study is the first to demonstrate that toxic responses to chemotherapy are accompanied by differential regulation of miRNAs with opposing effects on immune regulation. We find that a proinflammatory miRNA profile is sustained during the first three weeks after the transplantation, indicating that these miRNAs may play a role in the regulation of the inflammatory environment during immune reconstitution after HSCT.
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Authors
Peter L. Pontoppidan, Karina Jordan, Anting Liu Carlsen, Hilde Hylland Uhlving, Katrine Kielsen, Mette Christensen, Marianne Ifversen, Claus Henrik Nielsen, Per Sangild, Niels Henrik Helweg Heegaard, Carsten Heilmann, Henrik Sengeløv, Klaus Müller,