| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833029 | International Immunopharmacology | 2013 | 5 Pages |
Abstract
⺠Lactoferrin (LF) was examined to prevent septic events in a LPS-induced hypotension model in rats. ⺠LF Administration prior to LPS challenge enabled reduced mean arterial pressure (MAP) and reduced hypotensive response. ⺠Concurrent with reduction in MAP, LF administration allowed homeostasis of serum TNF-α and IL-6, but not TGF-β. ⺠LF demonstrated protection of proximal duodenal architectural integrity due to hypotensive changes.
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Authors
Marie-Francoise Doursout, Haley Horton, Linh Hoang, Yangyan Liang, Shen-An Hwang, Sydney Boyd, Jeffrey K. Actor, Marian L. Kruzel,