| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833033 | International Immunopharmacology | 2013 | 6 Pages |
Abstract
⺠Efficacy of PEG in reducing the immunogenicity of foreign proteins was evaluated. ⺠PEGylated antibodies immunogenicity was monitored in two strains of mice. ⺠The influence of PEGylation was found to be inconsistent. ⺠In contrary to the general assumption, PEG may increase protein immunogenicity. ⺠PEGylation impact on immunogenicity must be tested on an individual case basis.
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Authors
Tal Gefen, Jacob Vaya, Soliman Khatib, Natalia Harkevich, Fadi Artoul, E. Dan Heller, Jacob Pitcovski, Elina Aizenshtein,