Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5833075 | International Immunopharmacology | 2013 | 10 Pages |
Abstract
⺠Oridonin induced ROS generation in U937 cells and H2O2, OH were the dominant types. ⺠ROS was involved in oridonin-enhanced phagocytosis of apoptotic cells by U937 cells. ⺠ROS decreased MMP which was independent of the generation of ATP during engulfment. ⺠ROS promoted phagocytosis of apoptotic cells by an autophagy dependent mechanism. ⺠ROS mediated activation of PI3K-Akt and PLC γ-Ras-Raf-ERK signaling pathways.
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Authors
Linghe Zang, Hao He, Qian Xu, Yang Yu, Nan Zheng, Weiwei Liu, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima,