| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833273 | International Immunopharmacology | 2013 | 9 Pages |
Several lactic acid bacteria (LAB) demonstrably regulate the immune system and inhibit allergic disease. This study examined whether oral feeding of either Lactobacillus paracasei (L. paracasei) BB5 and/or Lactobacillus rhamnosus (L. rhamnosus) BB1 suppresses ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) and inflammation in a murine model. OVA-specific immune responses, cell profile of bronchoalveolar lavage fluid (BALF), and airway AHR were assessed following OVA and methacholine challenge. We investigated whether LAB can enhance CD4+FoxP3+ and CD8+FoxP3+ regulatory T (Treg) cells in splenic cells and apoptosis of CD4+IL-4+ T cells. Results found oral administration of combined LAB better than single L. paracasei or L. rhamnosus strain, improving Penh ratio after challenge with methacholine. High-dose combined LAB starkly decreased synthesis of OVA-specific IgE and IgG2a levels, as well as eosinophils infiltration in BALF. In addition, CD4+IL-4+ T cells decreased while CD4+FoxP3+ and CD8+FoxP3+ Treg cells increased significantly in splenic mononuclear cells of high-dose combined LAB group. Findings indicate allergen-induced AHR and airway allergic inflammation suppressed by enhances CD4+FoxP3+ and CD8+FoxP3+ Treg populations as well as Th1 cell response after treating with combined LAB. This study may provide a basis for developing a novel therapeutic or protective method for airway allergic disease.
⺠Combined L. paracasei BB5 and L. rhamnosus BB1 suppress OVA-induced AHR. ⺠Combined probiotics significantly improved Penh ratio. ⺠Combined probiotics decreased OVA-specific IgE and eosinophil infiltration. ⺠Combined probiotics suppress airway inflammation with apoptosis of CD4 + IL-4 + T cells.
