| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833484 | International Immunopharmacology | 2012 | 8 Pages |
Abstract
⺠Cucumarioside A2-2 interactions with mouse immune cell biomembranes were studied. ⺠Glycoside exhibited pronounced immunomodulatory activity in nanomolar concentrations. ⺠Glycoside effectively increased the microviscosity of the biomembrane lipid bilayer. ⺠It led to a reversible shift in membrane potential and [Ca2+]i increase in cytoplasm. ⺠Two binding sites for [3H]-cucumarioside A2-2 on cellular membranes were found.
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Authors
E.A. Pislyagin, R.V. Gladkikh, I.I. Kapustina, N.Yu. Kim, V.P. Shevchenko, I.Yu. Nagaev, S.A. Avilov, D.L. Aminin,