| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833489 | International Immunopharmacology | 2012 | 5 Pages |
Abstract
⺠Paeoniflorin is the major active constituent of the extract of Radix Paeoniae. ⺠Paeoniflorin is able to diminish pain, synovitis, and joint destruction in arthritis. ⺠Paeoniflorin suppresses the production of inflammatory mediators. ⺠Paeoniflorin inhibits the proliferation of lymphocytes and synovial fibroblasts. ⺠Paeoniflorin inhibits neovascularization, and matrix metalloproteinases production.
Keywords
ERKTNFHMEC-1TGPConAIκBNF-κBHUVECSConcanavalin AMmpsLPScollagen-induced arthritisRheumatoid arthritisinterleukinJoint destructionHuman umbilical vein endothelial cellsCIAAnti-inflammationAnalgesicVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)tumor necrosis factornuclear factor-κBlipopolysaccharideMatrix metalloproteinasesinhibitor of κBextracellular signal-regulated kinaseChinese herb
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Authors
Wei Zhang, Sheng-Ming Dai,