| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833525 | International Immunopharmacology | 2012 | 9 Pages |
Abstract
⺠We investigate the antitumor activities and safety of Ad-KDRscFv: sTRAIL. ⺠We established three adenovirus particles: Ad-KDRscFv, Ad-sTRAIL, and Ad-KDRscFv:sTRAIL. ⺠Ad-KDRscFv:sTRAIL showed the strongest tumoricidal effect by inhibiting the tumor growth and angiogenesis. ⺠KDRscFv:sTRAIL had no obvious toxicity to normal cells and tissues in vitro and in vivo. ⺠KDRscFv:sTRAIL may be useful in tumor therapy.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Liuqin Yang, Jun Guo, Jun Wang, Shunmei Wan, Shiming Yang, Rongquan Wang, Wensheng Chen, Guiyong Peng, Dianchun Fang,