Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression

► Celastrol inhibits IL-17A-induced RA-FLS migration and invasion. ► Celastrol inhibits IL-17A-induced RA-FLS motility by suppressing MMP-9 activity. ► Celastrol inhibits the binding activity of NF-κB in the MMP-9 promoter. ► Celastrol inhibits NF-κB-dependent transcriptional activation of MMP-9.