| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833556 | International Immunopharmacology | 2012 | 6 Pages |
Abstract
⺠We investigate the early effect of BMSCs on experimental PAH model rats and discussed the mechanism. ⺠BMSCs significantly improved the hemodynamic data and reduced the vascular remodeling of PAH. ⺠BMSCs significantly reduced the expression levels of inflammation factors such as IL-1β, IL-6, and TNF-α. ⺠BMSCs significantly decreased the protein levels of MMP-9, but increased the levels of VEGF. ⺠The protective effect of BMSCs maybe through modulation of inflammation and paracrine mechanism.
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Authors
Yun Luan, Xue Zhang, Feng Kong, Guang-Hui Cheng, Tong-Gang Qi, Zhao-Hua Zhang,