| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833573 | International Immunopharmacology | 2012 | 9 Pages |
Abstract
⺠We establish a mouse model of COPD induced by chronic cigarette smoke (CS) exposure. ⺠Chronic CS exposure intrigues increasing of Th17 prevalence and decreasing of Treg prevalence in lung and peripheral blood. ⺠Increasing of ROR-γt and decreasing FoxP3 mRNA is observed in mouse with chronic CS exposure. ⺠Th17/Treg imbalance may play a vital role in the breakdown of immune self-tolerance in COPD.
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Authors
Huaying Wang, Weidong Peng, Yuesong Weng, Huajuan Ying, Hequan Li, Dajing Xia, Wanjun Yu,