| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833574 | International Immunopharmacology | 2012 | 10 Pages |
Abstract
⺠The increase in the MHC class II expression induced by Nattectin, and CD49a are dependent on its lectin function. ⺠Nattectin induces MMP-9 production and endocytic capacity depends on lectin function. ⺠Nattectin induces M1 activation of macrophages. ⺠The influx of macrophages induced by Nattectin is totally dependent on IL-4 and IFN-γ. ⺠IL-4 is able to work as a coadjuvant with IFN-γ and IL-12 in the macrophage M1 polarization induced by Nattectin.
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Authors
Edson Kiyotaka Ishizuka, Marcio José Ferreira, Lidiane Zito Grund, Erica Maria Martins Coutinho, Evilin Naname Komegae, Alexandra Anjos Cassado, Karina Ramalho Bortoluci, Monica Lopes-Ferreira, Carla Lima,