Long-term amphetamine treatment exacerbates inflammatory lung reaction while decreases airway hyper-responsiveness after allergic stimulus in rats

► Long-term amphetamine treatment increases allergic lung inflammation in rats. ► Long-term amphetamine treatment reduces upper airway reactivity after allergic stimulus ► Amphetamine modulates the inflammatory lung reaction by IL-4, Mac-1, ICAM-1 and PECAM-1. ► Amphetamine abrogates the release of the anti-inflammatory cytokine IL-10.