| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833657 | International Immunopharmacology | 2012 | 9 Pages |
Abstract
⺠We constructed a bispecific antibody against both human IL-1β and IL-17A. ⺠A novel hinge element was used to replace the common GS linker. ⺠Cross-link assay proved that scBsAb1/17 binds to both its targets simultaneously. ⺠scBsAb1/17 is superior to its corresponding single-chain Ab in ease of RA models.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Jianying Qi, Fangming Kan, Xianlong Ye, Mo Guo, Yu Zhang, Guiping Ren, Deshan Li,