Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: Are AMPK and TLRs connected?

► Short term administration of metformin at myocardial infarction had a strong cardioprotective effects. ► Only the high dose of metformin increased phosphorylation of AMPKα. ► The increase of AMPK activity was associated with the reduction of TLR activity. ► The cardioprotective effects of metformin were AMPK-dependent and -independent. ► The AMPK dependent effects were associated with reduction of TLR activity.