Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

Article ID	Journal	Published Year	Pages	File Type
5833670	International Immunopharmacology	2011	13 Pages	PDF

Abstract

âº Lactic acid bacteria (LAB) are able to improve respiratory immunity. âº Mechanisms involved in the protective activity of LAB are suggested in this review. âº Selection of immunobiotic LAB should be based on innate immunity activation. âº LAB modulate the inflammatory response via the induction of IL-10 production. âº LAB's ability to regulate the inflammatory response is clue to avoid tissue damage.

Keywords

Bronchus associated lymphoid tissue GALT DCs TLR MHC-II MNC GEM PCV-7 PRRs inf PspA PspC BALT Nucleotide-binding oligomerization domain-like receptor PppA PsaA Nasal associated lymphoid tissue TNF MIP LPS BCD PFD cps NOD HSA MPO NALT pIgR LAB Heat stable antigen Adjuvant Streptococcus pneumoniae major histocompatibility complex II interferon interleukine BALF gut associated lymphoid tissue Lactic acid bacteria Toll-like receptor Protein-free diet Dendritic cells respiratory infection tumor necrosis factor lactate dehydrogenase LDH lipopolysaccharide Bronchoalveolar lavage fluid Immunocompromised hosts myeloperoxidase Vaccine macrophage inflammatory protein Pneumococcal surface protein A Capsular polysaccharide polymeric immunoglobulin receptor pattern recognition receptors