| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833679 | International Immunopharmacology | 2011 | 9 Pages |
Abstract
⺠An assay for detection of anti-CD28 mediated cytokine release is described. ⺠We tested 8 marketed mAbs for cytokine production similar to anti-CD28 superagonists. ⺠9 cytokines analyzed in addition to the previously published IL-6, INF-γ, and TNF-α. ⺠Multivariate hierarchical cluster analysis was used to analyze the data set. ⺠Results show that the test mAbs are distinct form anti-CD28 superagonists.
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Authors
Mindi R. Walker, Dorie A. Makropoulos, Ram Achuthanandam, Scott Van Arsdell, Peter J. Bugelski,