Article ID Journal Published Year Pages File Type
5833691 International Immunopharmacology 2011 6 Pages PDF
Abstract
► We constructed a cell model for the over-expression of SR-AI in human 293T cells in vitro. ► Overexpression of SR-AI in 293T cells led to increased oxLDL uptake and binding. ► Overexpression of SR-AI in 293T cells leads to pro-atherogenic changes. ► Overexpression of SR-AI induced cell apoptosis by downregulation of Bcl-2 expression and upregulation of Bak-1 expression.
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