| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833700 | International Immunopharmacology | 2011 | 7 Pages |
Abstract
⺠Treatment wth a S1P1 antagonist, W146, induces peripheral blood lymphopenia in mice. ⺠The pharmacokinetics of W146 explain its fast and short lasting lymphopenia. ⺠W146 also causes lung edema, due to the blockade of S1P1 receptor in endothelium. ⺠The lung edema and lymphopenia evoked by W146 show a similar time course. ⺠S1P1 agonists and antagonists cause the same in vivo effects with different kinetics.
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Authors
Gema Tarrasón, Mariona AulÃ, Sanam Mustafa, Vladislav Dolgachev, Maria Teresa Domènech, Neus Prats, MarÃa DomÃnguez, Rosa López, Nuria Aguilar, Marta Calbet, Mercè Pont, Graeme Milligan, Steven L. Kunkel, Nuria Godessart,