| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833706 | International Immunopharmacology | 2011 | 7 Pages |
Abstract
⺠CpG-DNA induces a known pro-inflammatory response in human macrophages. ⺠We show that the same CpG-DNA leads to an anti-inflammatory reaction in human endothelial cells. ⺠The anti-inflammatory endothelial response is characterized by IL-10 expression. ⺠Even in the presence of pro-inflammatory cytokines endothelia will maintain this Th2-like response towards CpG-DNA. ⺠This Th2-like endothelial response may be important for the adjuvant activity of CpG-DNA in immunization.
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Authors
N. Fitzner, L. Zahner, C. Habich, V. Kolb-Bachofen,