| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833745 | International Immunopharmacology | 2011 | 10 Pages |
Abstract
⺠The dose-dependent immunosuppressive effect of RV in preventing ADCC facilitated by hu14.18-IL2 immunotherapy in vitro. ⺠That RV at a tumor suppressive in vivo dose of 50 mg/kg is not immunosuppressive in vivo. ⺠This RV dose induces in vivo levels (1 mcM) that are not toxic to tumor cells or immune cells in vitro. ⺠Toxic effects of RV on immune and tumor cells in vitro are seen at RV levels â¥Â 25 mcM.
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Authors
Brenda L. Soto, Jacquelyn A. Hank, Soesiawati R. Darjatmoko, Arthur S. Polans, Eric M. Yanke, Alexander L. Rakhmilevich, Songwon Seo, KyungMann Kim, Ralph A. Reisfeld, Stephen D. Gillies, Paul M. Sondel,