Article ID Journal Published Year Pages File Type
5833806 International Immunopharmacology 2011 11 Pages PDF
Abstract
► Fish lectins are distributed in the epidermis, in the epithelia of the upper digestive tract and gills. ► A C-type lectin Nattectin was identified in the venom venomous fish Thalassophryne nattereri, through cDNA library. ► Dendritic cells can be used as immune adjuvants for the generation of antigen-specific immunity and lifelong immunologic memory. ► Nattectin induces the maturation of DCs from F4/80Rhigh macrophages, exhibiting T cell co-stimulatory molecules and IL-12 production. ► Nattectin promote T cell differentiation with production of Th1 cytokines.
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