| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833837 | International Immunopharmacology | 2011 | 5 Pages |
Abstract
⺠Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 were examined. ⺠Minimum effective concentration (MEC) was 0.13-0.2 ng/mL in acute dermatitis model. ⺠Maintenance of the MEC for at least 10-12 h was necessary for NC/Nga mice. ⺠The dose regimen for human atopic dermatitis treatment was determined by this study. ⺠Providing the information for determining dose regimen without appropriate biomarker.
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Authors
Atsuto Ogata, Yusuke Fujieda, Maki Terakawa, Tsuyoshi Muto, Taisaku Tanaka, Hiroshi Maruoka, Kazuhiro Nagahira, Yoshiaki Fukuda, Yoshiaki Tomimori, Naohiro Watanabe,