CD4+ T cell depletion changes the cytokine environment from a TH1/TH2 response to a TC17-like response in a murine model of atopic dermatitis

► Sensitization and challenges with the hapten FITC-induce AD-like disease in NC/Nga mice. ► CD4 depletion changes the cytokine environment and increases IL-17A and IL-22 production in a FITC induced NC/Nga mouse model. ► Immunohistochemistry suggests a Tc17-like response following CD4 depletion in a FITC induced NC/Nga mouse model.