| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833921 | International Immunopharmacology | 2012 | 8 Pages |
Abstract
⺠Wogonin can induce apoptosis in human breast cancer MCF-7 cells. ⺠Wogonin induces apoptosis via regulating the expression of bcl-2,Bax, P53 and survivin. ⺠Both PI3K-AKT and MAPK/ERK pathways play a key role on wogonin induces apoptosis. ⺠Wogonin down-regulates survivin,a downstream target of the PI3K/AKT pathway. ⺠The activation of caspase-3 play a important role on wogonin-induced -apoptosis.
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Authors
K.F. Huang, G.D. zhang, Y.Q. Huang, Y. Diao,