Inhibition of the NF-ÎºB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

Article ID	Journal	Published Year	Pages	File Type
5833926	International Immunopharmacology	2012	10 Pages	PDF

Abstract

âº EF31 is a potent inhibitor of IÎºÎ² kinase, NF-ÎºB translocation, and NF-ÎºB DNA-binding activity in RAW264.7 macrophages. âº EF31 blocks the expression of pro-inflammatory cytokine mRNA and protein. âº EF31 inhibits MAPK transcription factors. âº EF31 exhibits potent anti-cancer activity in various cancer cell lines.

Keywords

Fisher's least significant difference PKC AP-1 TLR-4 TAK1 Gadd45β ERK XIAP MD-2 MDA-MB-231 Jnk MIA PaCa-2 DMEM TNF LPS EF24 A2780 NF-κB ATF-2 PBS c-Jun N-terminal kinase DMSO MAPK Dulbecco's modified Eagle's medium inflammation Fluorescence resonance energy transfer FRET interleukin analysis of variance ANOVA Thiol cluster of differentiation Dimethyl sulfoxide Human breast cancer cells Anti-cancer myeloid differentiation factor 2 tumor necrosis factor Nuclear factor-kappa B activating transcription factor-2 lipopolysaccharide Macrophages Phosphate-buffered saline X-linked Inhibitor of Apoptosis Protein activator protein 1 Protein kinase C mitogen-activated protein kinase Pten Curcumin extracellular-signal-regulated kinase Toll-like receptor 4