| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5833965 | International Immunopharmacology | 2013 | 4 Pages |
Abstract
The objective of this study was to evaluate the immunomodulatory effects of a native 3.2Â kDa polypeptide of velvet antler from sika deer (nVAP32) on BALB/c mice immunocytes. In vitro tests showed that nVAP32 significantly stimulated splenocyte proliferation and enhanced the NK cytotoxicity and CD4+/CD8+ cell subpopulations. Also, nVAP32 demonstrated a significant capacity in up- and down-regulating the expression of Th1- and Th2-related cytokines respectively. These results indicated that nVAP32 might have potential immunomodulatory effects on the immune system of mice and the further investigation on in vivo effects is qualified.
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Authors
Zha Enhui, Li Xingxia, Li Dandan, Guo Xuesong, Shenyang Gao, Yue Xiqing,