Article ID Journal Published Year Pages File Type
5834151 International Immunopharmacology 2012 9 Pages PDF
Abstract
► Imipramine is a tricyclic antidepressant. ► Imipramine inhibits NF-κB-mediated CXCL1 expression in astrocytes. ► Astrocyte-derived CXCL1 facilitates microglial cell migration. ► Imipramine inhibits microglial cell migration. ► Imipramine exerts suppressive effects on neuroinflammation.
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Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes
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