| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5834163 | International Immunopharmacology | 2012 | 8 Pages |
Neuromediators such as dopamine (DA), serotonin (5-HT) and neuroopioids are known to be involved in the immune response control. This review has summarized the evidence supporting roles for brain DA (D1, D2), 5-HT (5-HT1A, 5-HT2A) and opioid (mu, delta, kappa) receptor subtypes in regulating immune function. Activation of postsynaptic D1- and D2-receptors produced immunostimulation while their blockade or activation of presynaptic D2-receptors mediated an immunoinhibitory effect. Activation of mu- and delta1-opioid receptors also increased the immune reaction intensity. Activation of postsynaptic 5-HT1A-, 5-HT2A-receptors, delta2- and kappa-opioid receptors resulted in immunosuppression while the blockade of postsynaptic 5-HT1A-, 5-HT2A-receptors or activation of somatodendritic 5-HT1A-autoreceptors resulted in the immune response stimulation. Immunomodulating effects of drugs acting at various mediator and opioid receptor subtypes depend on the initial psychoemotional state of animals (aggression, submission, depression). The presented data may have implications for the treatment of emotional stress and mental disorders associated with changes in activity of brain DA, 5-HT, opioid systems and their receptor function as well as immune reactivity.
⺠Brain dopamine, serotonin and opioid systems are involved in immunomodulation. ⺠Dopamine D1-, D2- and opioid μ-, δ1-receptors play a key role in immunostimulation. ⺠Serotonin 5-HT1A-, 5-HT2A-, opioid δ2-, κ-receptors contribute to immunosuppression. ⺠Effects of drugs influencing certain receptors on immunity depend on emotional state. ⺠The data may have implications for the treatment of emotional and mental disorders.
