Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5841398 | Life Sciences | 2016 | 7 Pages |
Abstract
Our data revealed specific signaling pathways in alleviating CA-evoked global cerebral ischemia by elucidating that HIF-1α plays an important role in regulating expression of VEGFR-2 and Caspase-3 as well as improving neurological functions and neuronal edema. The subsequent induction of HIF-1α and its target signal pathways is likely a part of the intrinsic neuroprotective effects aimed at attenuating damage as a result of global cerebral ischemia. Thus, targeting one or more of these signaling molecules has clinical implications for treatment and management of CA-evoked global cerebral ischemia often observed in clinics.
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Authors
Xiao-Liang Liu, Jian Lu, Jihong Xing,