Low epinephrine levels and selective deficiency of β2-adrenoceptor vasodilation at birth

In rabbits, as well as in humans, β2-adrenoceptor-mediated responses and epinephrine synthesis are both immature at birth. On the other hand, the β1 and β3-adrenoceptor-mediated responses are fully developed. We conclude that epinephrine may influence the development of the β2-adrenoceptor-mediated responses at birth and the rabbit is an excellent model to study these issues.