| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5841442 | Life Sciences | 2016 | 31 Pages |
Abstract
Bile acids significantly modulate metabolic and drug associated gene networks that are connected to distinct shifts in the microRNAome These findings give novel insights on how BA enfold metabolic and system toxic effects.
Keywords
FABPHMGCS2RT-PCRSHPmicroRNA-34aCpt1aSULTAGPAT2NPC1L1LDLRSLCOATPABCS1PRCDCABSEPFXRNtcpMicroRNA profilingNAFLDNa+-taurocholate cotransporting polypeptidePPAR-γAHR1-Acylglycerol-3-phosphate O-acyltransferasemRNACyPorganic anion transport proteinSTARD3AKR1C1FDRUGTBAsDMSOfarnesoid X receptorprimary human hepatocytesReal-time PCRmessenger RNAUDP-glucuronosyltransferaseAsbtapoapolipoproteinnonalcoholic steatohepatitisChenodeoxycholic acidBile acidsOstNonalcoholic fatty liver diseaseATP-binding cassette transporterSolute carrier familyDimethyl sulfoxideorganic solute transportersulfotransferaseCytochrome P450small heterodimer partnerFasnDrug metabolismUTR یا untranslated regions untranslated regionfalse discovery rateMicroRNAMiRNANash polymerase chain reactionPCRFatty acid-binding proteinmRNA profilingBile salt export pumpcarnitine palmitoyltransferase 1aarylhydrocarbon receptorsphingosine-1-phosphate receptorperoxisome proliferator-activated receptorlow density lipoprotein receptor
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Authors
Regina Krattinger, Adrian Boström, Serene M.L. Lee, Wolfgang E. Thasler, Helgi B. Schiöth, Gerd A. Kullak-Ublick, Jessica Mwinyi,