Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5841705 | Life Sciences | 2015 | 10 Pages |
Abstract
These results seemingly suggest that the high apoptotic threshold of CSCs to doxorubicin-induced cell dead stimuli is mainly dependent on the drug concentration reaching tumor cells that are governed by efflux transporter activity. Therefore, modulation of these transporters may be effective in potentiating the pro-apoptotic effects of doxorubicin, and emerges as an attractive strategy to sensitize osteosarcoma CSCs to chemotherapy.
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Authors
Cláudia Gonçalves, Sara R. Martins-Neves, Daniela Paiva-Oliveira, Vitor E.B. Oliveira, Carlos Fontes-Ribeiro, Célia M.F. Gomes,