| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5842452 | Life Sciences | 2012 | 6 Pages |
Abstract
These data indicate that SOL1 is primarily a NEP inhibitor in vitro as well as in vivo. Given the preferential renal accumulation and renal clearance of SOL1 additional ECE-1 inhibition in the kidney may have contributed to its chronic BP lowering effects in the DOCA-salt hypertensive rat model.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
J. Nelissen, P. Lemkens, H. Sann, M. Bindl, F. Bassissi, D. Jasserand, J.G.R. De Mey, B.J.A. Janssen,