An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats

These results suggest that α1-AR facilitates the micturition reflex in the spinal cord, and α1-AR blockers applied in the lumbosacral spinal inhibits this effect. Upregulation of α1-AR in the lumbosacral spinal cord could be involved in the genesis of detrusor overactivity after SCI. Therefore, if α1-AR blockers pass the blood-brain barrier, they could act in the spinal cord to improve storage function in patients with detrusor overactivity (DO).