Article ID Journal Published Year Pages File Type
5842751 Life Sciences 2012 8 Pages PDF
Abstract
Endogenous H2S transiently and reversibly inhibits SR Ca2 + uptake in rat heart SR because of downregulated SERCA activity associated with PLB phosphorylation by the PI3K/Akt or KATP channel. The transient negative regulation of SR Ca2 + uptake and the L-type Ca2 + channel contributes to Ca2 + cycle homeostasis, which might be an important molecular mechanism in ischemic diseases.
Keywords
Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Preview
Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca2 + uptake via KATP channel and PI3K/Akt pathway
Authors
, , , , , ,