Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5842877 | Life Sciences | 2011 | 8 Pages |
Abstract
These results demonstrate that U50,488H administered immediately prior to reperfusion increases Akt phosphorylation through a PI3-kinase-dependent mechanism and reduces postischemic myocardial apoptosis. Phosphorylation of eNOS with secondary NO production contribute significantly to the anti-apoptotic effect of U50,488H postconditioning.
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Authors
Guang Tong, Zhongchan Sun, Xufeng Wei, Chunhu Gu, Alan David Kaye, Yuemin Wang, Juan Li, Quanyu Zhang, Haitao Guo, Shiqiang Yu, Dinghua Yi, Jianming Pei,