Glutamatergic plasticity and alcohol dependence-induced alterations in reward, affect and cognition

Article ID	Journal	Published Year	Pages	File Type
5844238	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2016	53 Pages	PDF

Abstract

While pharmacological treatments for alcohol dependence and relapse targeting the glutamatergic system have shown great promise in preclinical models, more research is needed to uncover novel, possibly circuit-specific, therapeutic targets that exhibit improved efficacy and reduced side effects.

Keywords

RMTg VTA OFC PAG MSN MPFC NMDA PRL BNST mGluR LHb AMPA DMS rostromedial tegmental nucleus AMPA receptor subunits NAC Periacqueductal gray N-methyl-d-asparate DLS PFC MEA CeA EPSP iGluR dorsolateral striatum dorsomedial striatum Addiction long-term depression Withdrawal Negative Affect long-term potentiation LTP lateral habenula relapse prefrontal cortex orbitofrontal cortex medial prefrontal cortex prelimbic cortex Cerebrospinal fluid CSF LTD ventral tegmental area medium spiny neuron Nucleus accumbens bed nucleus of the stria terminalis Medial nucleus of the amygdala NMDA receptor subunits excitatory postsynaptic potential Plasticity external capsule glutamate Metabotropic glutamate receptor ionotropic glutamate receptor