Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5844260 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2016 | 26 Pages |
Abstract
This study provides the first evidence of: (i) a significant decrease of mtDNAcn in combat PTSD, (ii) a possible “inverted-U” shaped relationship between PTSD symptom severity and mtDNAcn within PTSD subjects, and (iii) a direct correlation of mtDNAcn with positive affectivity within PTSD subjects. Altered mtDNAcn in PTSD may reflect impaired energy metabolism, which might represent a novel aspect of its pathophysiology.
Keywords
NSAIDSClinician Administered PTSD ScaleTBIMitochondrial DNA copy numberBDI-IICAPSPGC-1αPBMCsSCIDDLPFCANCOVAMDDMitochondrial DNAROSAdenosine TriphosphateATPTraumatic brain injuryETIpost-traumatic stress disorderPTSDMajor depressive disorderPositive affectTERTanalysis of covarianceTelomerase reverse transcriptaseWar veteransNon-steroidal anti-inflammatory drugsmtDNAperipheral blood mononuclear cellsbody mass indexBMIMitochondriaNitric oxideBeck Depression Inventory-IIPANASReactive oxygen species
Related Topics
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Neuroscience
Biological Psychiatry
Authors
Francesco Saverio Bersani, Claire Morley, Daniel Lindqvist, Elissa S. Epel, Martin Picard, Rachel Yehuda, Janine Flory, Linda M. Bierer, Iouri Makotkine, Duna Abu-Amara, Michelle Coy, Victor I. Reus, Jue Lin, Elizabeth H. Blackburn, Charles Marmar,