Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5844299 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2016 | 46 Pages |
Abstract
Major depressive disorder (MDD) is a serious health concern worldwide. Currently there are no predictive tests for the effectiveness of any particular antidepressant in an individual patient. Thus, doctors must prescribe antidepressants based on educated guesses. With the recent advent of scientific research, genome-wide gene expression microarray studies are widely utilized to analyze hundreds of thousands of biomarkers by high-throughput technologies. In addition to the candidate-gene approach, the genome-wide approach has recently been employed to investigate the determinants of MDD as well as antidepressant response to therapy. In this review, we mainly focused on gene expression studies with genome-wide approaches using RNA derived from peripheral blood cells. Furthermore, we reviewed their limitations and future directions with respect to the genome-wide gene expression profiling in MDD pathogenesis as well as in antidepressant therapy.
Keywords
IRF7DUSP1dual specificity phosphatase 1IL1bPPLEDN1CNVsTIMP1PCDH10IFITM3mRNAsPPT1NTRK2PSMA6ZBTB16LPSPROK2MATR3Palmitoyl-protein thioesterase 1MLC1Transgelin 2RPL5LCLSFK506 binding protein 5TNFTAGLN2ribosomal protein L5CD97PLSCR1Ribosomal protein L9N-methyl-d-aspartateITGB3NMDAlncRNAsncRNAsMDDPBMCsCHL1SNPsmiRNAsNESDAMDEFKBP5BDNFnoncoding RNAslong noncoding RNAsMessenger RNAsMajor depressive disorderendothelin 1interleukin 1 betalymphoblastoid cell linesAntidepressantsmicroRNAsperipheral blood mononuclear cellsInterferon regulatory factor 7Brain-derived neurotrophic factortumor necrosis factorPhospholipid scramblase 1Major depressive episodelipopolysaccharideMatrin 3METTranscriptional profilingProkineticin 2periplakinSingle nucleotide polymorphismsgranzyme A
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Authors
Eugene Lin, Shih-Jen Tsai,