| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5844361 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2014 | 10 Pages |
â¢Inflammatory is a critical upstream event in bipolar disorder and type-2 diabetes.â¢Inflammation in bipolar disorder may heighten vulnerability for type-2 diabetes.â¢Add-on anti-inflammatory/anti-diabetic agents may lessen bipolar disorder burden.
IntroductionBipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood.ObjectivesThe purpose of this review is to critically review evidence suggesting that inflammation may have an important role in the development of both BD and T2D.ResultsThe literature covered in this review suggests that inflammatory dysregulation take place among many BD patients. Such dysregulated and low grade chronic inflammatory process may also increase the prevalence of T2D in BD population. Current evidence supports the hypothesis of dysregulated inflammatory processes as a critical upstream event in BD as well as in T2D.ConclusionsInflammation may be a factor for the development of T2D in BD population. The identification of inflammatory markers common to these two medical conditions will enable researchers and clinicians to better understand the etiology of BD and develop treatments that simultaneously target all aspects of this multi-system condition.
