Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5844411 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2014 | 7 Pages |
Abstract
Alcohol abuse and dependence are a rapidly growing problem with few treatment options available. The zebrafish has become a popular animal model for behavioral neuroscience. This species may be appropriate for investigating the effects of alcohol on the vertebrate brain. In the current review, we examine the literature by discussing how alcohol alters behavior in zebrafish and how it may affect biological correlates. We focus on two phenomena that are often examined in the context of alcohol-induced neuroplasticity. Alcohol tolerance (a progressive decrease in the effect of alcohol over time) is often observed following continuous (chronic) exposure to low concentrations of alcohol. Alcohol sensitization also called reverse tolerance (a progressive increase in the effect of alcohol over time) is often observed following repeated discrete exposures to higher concentrations of alcohol. These two phenomena may underlie the development and maintenance of alcohol addiction. The phenotypical characterization of these responses in zebrafish may be the first important steps in establishing this species as a tool for the analysis of the molecular and neurobiological mechanisms underlying human alcohol addiction.
Keywords
qPCRCPPALDH2ADH5HIAADOPACSLCQTL3, 4-dihydroxyphenylacetic acid5-Hydroxyindoleacetic acidAChEEthanolAcetaldehyde dehydrogenaseAcetylcholinesterasegamma-aminobutyric acidAlcohol addictionAlcohol dehydrogenaseAlcohol toleranceconditioned place preferenceQuantitative trait locisolute carrierBehavioral phenotypingwild-typequantitative polymerase chain reactionHigh pressure liquid chromatographyHPLCGABAZebrafish
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Authors
Steven Tran, Robert Gerlai,